Publication: Innate TCRβ-chain engagement drives human T cells toward distinct memory-like effector phenotypes with immunotherapeutic potentials

Publication: Innate TCRβ-chain engagement drives human T cells toward distinct memory-like effector phenotypes with immunotherapeutic potentials

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Marengo Therapeutics, Inc. (Marengo) is a clinical-stage biotech company pioneering a new way to activate T cells by targeting germline-encoded alleles in the chain of the T cell receptor (TCR) to selectively activate the right T cell subsets to fight cancer. Bridge Informatics is proud to have contributed to an article Marengo published in Science Advances.

As explained in Marengo’s press release, the publication “highlights the distinct binding modes of Marengo’s V chain-targeting antibodies and their effects on differentiation states of human T cells. Using a battery of immunophenotyping and molecular approaches, researchers in Professor Hayday’s Immunobiology Lab at King’s College London revealed a unique signature induced in subsets of human T cells treated with V chain-targeting antibodies.”

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Haider M. Hassan, Data Scientist, Bridge Informatics

Haider is one of our premier data scientists. He provides bioinformatic services to clients, including high throughput sequencing, data pre-processing, analysis, and custom pipeline development. Drawing on his rich experience with a variety of high-throughput sequencing technologies, Haider analyzes transcriptional (spatial and single-cell), epigenetic, and genetic landscapes.

Before joining Bridge Informatics, Haider was a Postdoctoral Associate at the London Regional Cancer Centre in Ontario, Canada. During his postdoc, he investigated the epigenetics of late-onset liver cancer using murine and human models. Haider holds a Ph.D. in biochemistry from Western University, where he studied the molecular mechanisms behind oncogenesis. Haider still lives in Ontario and enjoys spending his spare time visiting local parks. If you’re interested in reaching out, please email [email protected] or [email protected]

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