Publication: A T cell receptor β chain–directed antibody fusion molecule activates and expands subsets of T cells to promote antitumor activity

Publication: A T cell receptor β chain–directed antibody fusion molecule activates and expands subsets of T cells to promote antitumor activity

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By Seb Battaglia & Haider Hassan

Marengo Therapeutics, Inc. (Marengo) is a clinical-stage biotech company pioneering a new way to activate T cells  by targeting specificT cell receptors (TCRs)  to selectively activate the right T cell subsets in order to treat checkpoint inhibitor (CPI) refractory human cancers. Bridge Informatics is proud to have contributed to an article Marengo published in the latest edition of Science Translational Medicine.

As explained in Marengo’s press release, the publication “highlights the potent and durable antitumor activity of STAR0602 across a broad range of PD1-refractory murine and human solid tumor models via a mechanism that is distinct to checkpoint inhibitors and cytokine therapies.”

Click here to read the publication in Science Translational Medicine:

How Bridge Informatics Can Help With Publications

At Bridge Informatics, we believe your groundbreaking research deserves a compelling voice. We’re not just about producing polished manuscripts – our data scientists (who are experienced bench researchers) act as your dedicated partner in crafting impactful publications that resonate with the right audience and advance your scientific journey.

Here’s how we help with every step of the publication process:

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We help you craft impactful stories that elevate your research, accelerate your journey to market, and leave a lasting mark on the scientific community.

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Seb Battaglia, PhD, Senior Data Scientist, Bridge Informatics

Seb is a veteran computational biologist with more than ten years of experience and one of our senior Data Scientists. Seb uses profound biology and modern bioinformatics knowledge to solve complex problems for Bridge’s clients. He enjoys working on single-cell or bulk multidimensional datasets related to health and disease. Seb places a particular focus on understanding the relationship between the immune system and disease.

Seb’s primary role is to provide bioinformatics services to small biotech startups and large pharmaceutical companies. In addition, he acts as an advisor offering training, coaching, and mentorship to the wider Bridge Informatics team.

Currently, he is an Assistant Professor of Oncology at a National Cancer Institute (NCI) Designated Comprehensive Cancer Center, where he runs an Immunotherapy and Immunogenomics lab studying the relationship between prostate cancer and the immune system.

Before joining Bridge, Seb worked in both wet and dry laboratories. He holds a Ph.D. in Cancer Biology, a BSc/MSc in Medical Biotechnology, and an MS in Bioinformatics. Seb was born in Italy and currently lives in West New York. He spends his spare time training for endurance events and practicing martial arts.

Haider M. Hassan, Data Scientist, Bridge Informatics

Haider is one of our premier data scientists. He provides bioinformatic services to clients, including high throughput sequencing, data pre-processing, analysis, and custom pipeline development. Drawing on his rich experience with a variety of high-throughput sequencing technologies, Haider analyzes transcriptional (spatial and single-cell), epigenetic, and genetic landscapes.

Before joining Bridge Informatics, Haider was a Postdoctoral Associate at the London Regional Cancer Centre in Ontario, Canada. During his postdoc, he investigated the epigenetics of late-onset liver cancer using murine and human models. Haider holds a Ph.D. in biochemistry from Western University, where he studied the molecular mechanisms behind oncogenesis. Haider still lives in Ontario and enjoys spending his spare time visiting local parks. If you’re interested in reaching out, please email [email protected] or [email protected]

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